Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH
نویسندگان
چکیده
Enzymes are regulated by their activation and inhibition. Enzyme activators can often be effective tools for scientific and medical purposes, although they are more difficult to obtain than inhibitors. Here, using the paired peptide method, we report on protease-cathepsin-E-activating peptides that are obtained at neutral pH. These selected peptides also underwent molecular evolution, after which their cathepsin E activation capability improved. Thus, the activators we obtained could enhance cathepsin-E-induced cancer cell apoptosis, which indicated their potential as cancer drug precursors.
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عنوان ژورنال:
دوره 2012 شماره
صفحات -
تاریخ انتشار 2012